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Relationship About Pregnancy Health and Offspring Developmental &Behavioral Outcomes

NCT04017286 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 3000

Last updated 2021-02-01

No results posted yet for this study

Summary

This topic puts forward a hypothesis: genetic and environmental factors such as major depressive disorder during pregnancy, nutritional status of vitamin A, D, E, and folic acid, intestinal microecology, and bisphenol A exposure, may affect the cognitive development level of the offspring through the genetic correlation with attention deficit hyperactivity disorder, developmental delay/intellectual disability, and major depressive disorder, allelic heterogeneity and pleiotropy of ITIH3 mediated by SNP and CACNB2, neurotransmitters like dopamine, and metabolic pathways, thereby increasing the risk of attention deficit hyperactivity disorder and developmental delay/intellectual disability prevalence on offspring.

This topic planning from allelic heterogeneity and pleiotropy of attention deficit hyperactivity disorder and major depressive disorder mediated by SNP, neurotransmitters like dopamine, and metabolic pathways, explores deeply the influences on children's development level and the risk of common neurological disorder caused by genetic and environmental factors during pregnancy, looking for reasonable prevention, early diagnosis of biomarkers and therapeutic targets, in order to provide data support for further improvement and revision of national mother and infant healthcare policy .

Conditions

  • Children Behavior Problem
  • Pregnancy

Sponsors & Collaborators

  • Chen Li

    lead OTHER

Principal Investigators

  • Li Chen, MD · Children's Hospital of Chongqing Medical University

  • Tanya Froehlich, MD,MS · Children's Hospital Medical Center, Cincinnati

  • yu T Li, MS · Children's Hospital of Chongqing Medical University

Eligibility

Min Age
3 Months
Max Age
72 Months
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-07-01
Primary Completion
2025-07-31
Completion
2028-12-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04017286 on ClinicalTrials.gov