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Delayed Cerebral Ischaemia and Coagulation Alterations After Aneurysmal Subarachnoid Haemorrhage

NCT03985176 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 62

Last updated 2022-11-10

No results posted yet for this study

Summary

Despite the advances in neurosurgical and -radiological techniques and intensive care, the mortality and morbidity rates in SAH have not changed in recent years. There is still only a limited understanding of the mechanisms of secondary insults causing brain injury after SAH, also called delayed cerebral ischemia (DCI).

In this study, the investigators are exploring the use of quantifiable biomarkers from blood and continuous EEG monitoring as tools for the diagnostics of DCI. Additionally, the investigators are looking into other clinical variables (eg. pain, heart function) as factors of DCI.

Conditions

  • Aneurysmal Subarachnoid Hemorrhage

Interventions

DEVICE

ROTEM

ROTEM measurements 24,48, 72, 120, 192 and 288 hours from aneurysmal SAH

PROCEDURE

EEG

Continuous EEG-monitoring after aneurysm treatment until patient transferred to ward or up to 14 days after aneurysmal SAH

PROCEDURE

bilateral compression ultrasound of the lower extremity veins

to exclude asymptomatic deep venous thrombosis once over days 3 to 7

Sponsors & Collaborators

  • Tampere University Hospital

    lead OTHER

Principal Investigators

  • Simo Varila · Tampere University Hospital

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-06-10
Primary Completion
2022-03-31
Completion
2025-12-31

Countries

  • Finland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03985176 on ClinicalTrials.gov