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Thromboelastometry and Ischemic Stroke (ThromboPredict)

NCT04870684 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 200

Last updated 2021-05-03

No results posted yet for this study

Summary

In ischemic stroke, the recanalization rate after intravenous thrombolysis has been estimated to be less than 50% in patients with proximal intracranial artery occlusion; this rate is greater than 80% after endovascular thrombectomy. Thromboelastometry is a method of analysis of coagulation and fibrinolysis in whole blood. The main objective of this study is to evaluate whether the parameters obtained by thromboelastometry are predictive of revascularization at arteriography during mechanical thrombectomy, after treatment with rt-PA thrombolysis.

Conditions

  • Cerebrovascular Stroke
  • Thrombolytic Therapy
  • Mechanical Thrombectomy

Interventions

OTHER

thromboelastometry test

This study does not modify the usual care of the patient. Only 5 citrated tubes (maximum 15 mL of blood) are collected in addition to the initial emergency department sample (routine care). The patient's care follows the classic thrombolysis alert pathway. There is no additional complementary examination or additional neurological evaluation. Clot formation kinetics will be evaluated by thromboelastometry to determine the predictive parameters of revascularization. Clot formation and lysis parameters as well as revascularization according to thrombo-inflammation processes will be studied.

Sponsors & Collaborators

  • University Hospital, Caen

    lead OTHER

Principal Investigators

  • Richard Macrez, Doctor · University hospital of Caen and faculty of medicine

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-05-01
Primary Completion
2024-04-30
Completion
2024-05-01

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04870684 on ClinicalTrials.gov