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Drivers of Hypoxia-induced Angiogenesis in Tumor Development

NCT03979833 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 10

Last updated 2019-09-27

No results posted yet for this study

Summary

The study aims to elucidate hypoxia-induced angiogenesis in tumor development using central nervous system (CNS) hemangioblastoma tumorgenesis as a model.

In a pilot-project the investigators will identify genetic drivers of CNS hemangioblastoma progression and associated cyst development using whole genome sequencing and copy number profiling of tumor DNA paired with clinical information about each tumor's growth pattern. The investigators will look for recurrent mutations across tumors to identify common genetic mechanisms involved in early tumorigenesis.

Conditions

  • Von Hippel-Lindau Disease

Interventions

GENETIC

Whole exome sequencing

DNA from CNS hemangioblastomas and normal tissue (blood) will be analysed using whole exome sequencing.

Sponsors & Collaborators

  • Odense University Hospital

    collaborator OTHER

  • University of Copenhagen

    lead OTHER

Principal Investigators

  • Ole William Petersen, MD, PhD · Head of department

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-06-14
Primary Completion
2019-08-31
Completion
2020-05-31

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03979833 on ClinicalTrials.gov