Improving Antibiotic Prescribing for Urinary Tract Infections in Frail Elderly

Summary

The purpose of this study is to determine whether a tailored multifaceted antibiotic stewardship intervention reduces antibiotic use for urinary tract infections in residential care homes and nursing homes attended by general practitioners. This will be evaluated in a pragmatic cluster randomised controlled trial using a modified community-based participatory action research approach.

Conditions

• Urinary Tract Infections

Interventions

OTHER

antibiotic stewardship intervention

The intervention is multifaceted, consisting of the implementation of an algorithm for restrictive use of antibiotics as proposed in recent guidelines (Verenso, Dutch guideline), tailored in close collaboration with local stakeholders to the specific implementation setting, by means of a modified participatory-action research (PAR) approach. To support the process of intervention-tailoring and -implementation, a toolbox comprising of materials, aids and actions is developed to be used at the discretion of the local stakeholders to support implementation of the algorithm.The algorithm is congruent with the Swedish and Norwegian guidelines, which also promote more restrictive use of antibiotics in case of non-specific symptoms, even though the algorithm is more detailed.

Sponsors & Collaborators

• UMC Utrecht

  collaborator OTHER

• Medical University of Lodz

  collaborator OTHER

• University of Oslo

  collaborator OTHER

• Vastra Gotaland Region

  collaborator OTHER_GOV

• Göteborg University

  collaborator OTHER

• Cees Hertogh

  lead OTHER

Principal Investigators

• Cees MP Hertogh, prof. dr. · Amsterdam UMC, location VUmc

• Theo JM Verheij, prof. dr. · UMC Utrecht

• Maciek Godycki-Cwirko, prof.dr. · Medical University of Lodz

• Morten Lindbæk, prof. dr. · University of Oslo

• Pär-Daniel Sundvall, MD PhD · Göteborg University

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

70 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2019-09-01

Primary Completion

2021-07-21

Completion

2021-07-21

Countries

• Netherlands
• Norway
• Poland
• Sweden

Study Locations