Dipsticks and Microscopy to Reduce Antibiotic Use in Women's Urinary Tract Infections: a Pilot Trial (MicUTI)

Summary

With the aim to pilot a full-scaled trial to reduce unnecessary antibiotics in women with suspected uncomplicated urinary tract infections, twenty general practices in Bavaria, Germany, will be randomized to deliver patient management based on phase-contrast microscopy and urinary dipsticks or to usual care. Primary endpoints are recruitment and retention rates.

Conditions

• Cystitis Acute
• Antibiotic Resistant Infection
• Medication Adherence
• Urinary Tract Infection Bacterial
• Urinary Tract Infection Lower Acute

Interventions

DIAGNOSTIC_TEST

Point-of-care microscopy and dipstick guided management

GPs will be encouraged to apply the following diagnosis and treatment algorithm (figure 1) to consenting women, taking their preferences into account: 1. If POCTs are positive for bacteria by microscopy and/or for erythrocytes by dipsticks the GP issues, at his/her own clinical judgement, a delayed or immediate prescription for an antibiotic.10 In the MicUTI intervention, delayed prescription is defined as issuing an antibiotic prescription with the advice to take the medication only when symptoms do not improve or worsen in 48 hours. 2. If POCTs are negative for bacteria and erythrocytes, the GP advises for self-help remedies according to guidelines and to do without antibiotics Study specific training in point-of-care microscopy will be provided to intervention practices.

Sponsors & Collaborators

• University Hospital Erlangen

  collaborator OTHER

• LMU Klinikum

  collaborator OTHER

• University of Bristol

  collaborator OTHER

• University of Santiago de Compostela

  collaborator OTHER

• Università degli Studi di Trento

  collaborator OTHER

• University of Wuerzburg

  collaborator OTHER

• University of Georgia

  collaborator OTHER

• Wuerzburg University Hospital

  lead OTHER

Principal Investigators

• Ildikó Gágyor, Professor · University Hospital Wuerzburg

Study Design

Allocation

RANDOMIZED

Purpose

OTHER

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

70 Years

Sex

FEMALE

Healthy Volunteers

No

Timeline & Regulatory

Start

2023-06-15

Primary Completion

2024-04-30

Completion

2024-04-30

Countries

• Germany

Study Locations