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IPACK Study in Total Knee Arthroplasty Patients

NCT03954379 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 78

Last updated 2022-04-29

No results posted yet for this study

Summary

This study proposes to compare current multimodal analgesic treatment for TKA with a new multimodal analgesic regimen to demonstrate decreased opioid requirement, time to rehabilitation, and time to reach hospital discharge.

Conditions

  • Knee Replacement Arthroplasty

Interventions

DRUG

Standard of Care (ACB, SA, peri-op pain management)

INTERVENTION BEFORE SURGERY Adductor Canal Block will be done using Adductor canal catheter (tube in the thigh) + injection of freezing medication INTERVENTION DURING SURGERY IV propofol for sedation INTERVENTION AFTER SURGERY Injection of salty water through the tube in the thigh x 2

DRUG

IPACK and multi-modal analgesic regimen

INTERVENTION BEFORE SURGERY 1. Adductor Canal Block will be done using Adductor canal catheter (tube in the thigh) + injection of freezing medication 2. iPACK block ( infiltration between Popliteal Artery and posterior Capsule of the Knee) - injection of freezing medication in the back of the knee INTERVENTION DURING SURGERY 1. IV dexmedetomidine 2. IV ketamine Both for sedation INTERVENTION AFTER SURGERY 1. injection of freezing medication through the tube in the thigh x 2 2. IV dexamethasone 8 mg 1 day after surgery

PROCEDURE

Periarticular Local Anesthetic Infiltration

INTERVENTION DURING SURGERY

DRUG

IV Dexamethasone 8mg at the end of surgery as standard of care

INTERVENTION DURING SURGERY

Sponsors & Collaborators

  • University Health Network, Toronto

    lead OTHER

Principal Investigators

  • Vincent Chan, MD · University Health Network, Toronto

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-10-24
Primary Completion
2020-12-02
Completion
2021-03-31

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03954379 on ClinicalTrials.gov