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Opioids Versus Non-Opioids Postoperative After Knee Arthroscopic Surgery

NCT03858231 · Status: RECRUITING · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 148

Last updated 2026-02-10

No results posted yet for this study

Summary

The purpose of this study is to look at pain management with opioids versus non-opioids after knee arthroscopy. This study will determine 1) whether the most commonly used non-narcotic medications provide pain relief comparable with the most commonly prescribed narcotic medications in patients undergoing arthroscopic knee surgery, and 2) whether patients' characteristics (gender, pre-operative knee symptoms, workers compensation status and employment status) affect pain level following surgery or medication usage.

Conditions

  • Knee Injuries
  • Pain, Postoperative
  • Opioid Use

Interventions

DRUG

Norco 5Mg-325Mg Tablet

1 tablet up to 4 times per day for 7 days

DRUG

Ibuprofen 600 mg

1 tablet up to 4 times per day for 7 days

DRUG

Acetaminophen 325Mg Tab

1 tablet up to 4 times per day for 7 days

Sponsors & Collaborators

  • Sanford Health

    lead OTHER

Principal Investigators

  • Bruce Piatt, MD · Sanford Health

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-10-29
Primary Completion
2027-12-31
Completion
2028-01-31
FDA Drug
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03858231 on ClinicalTrials.gov