Clinical Impact of the FilmArray Blood Culture Identification Panel Performed on Positive Blood Cultures From Intensive Care Patients With Septicemia
NCT03943719 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 139
Last updated 2019-05-09
Summary
Molecular testing is a largely validated approach allowing rapid identification of positive blood cultures. However, due to its high cost and its limited information on susceptibility, it is considered as an add-on technique reserved for specific patient populations. In our study, we specifically evaluated molecular testing in a critical care setting and measured its impact on the therapeutic management of critically ill with positive blood cultures. Through the analysis of 110 positive blood culture episodes included in both pre- and post intervention period, we measured a drastic 14h-reduction of the time to administration of the optimal antimicrobial treatment with the use of the molecular approach.
Conditions
- Septicemia
Interventions
- DIAGNOSTIC_TEST
-
FilmArray blood culture identification panel
FilmArray blood culture identification panel is performed 24 hours on 24hours and 7 days a week on positive blood cultures to accelerate pathogens detection
Sponsors & Collaborators
-
BioMérieux
collaborator INDUSTRY -
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
lead OTHER
Principal Investigators
-
Alexia VERROKEN · Cliniques universitaires St-Luc
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2017-03-01
- Primary Completion
- 2017-12-31
- Completion
- 2018-08-31
Countries
- Belgium
Study Locations
More Related Trials
-
Molecular Diagnosis and Risk Stratification of Sepsis
NCT01905033 ·Status: UNKNOWN
-
Evaluation of the Performance of a New Rapid Bacteremia Test in the Intensive Care Patient
NCT06241248 ·Status: COMPLETED
-
Evaluation in the Treatment of Nosocomial Sepsis Comparing Polymerase Chain Reaction With Conventional Blood Culture.
NCT01450358 ·Status: COMPLETED ·Phase: PHASE4
-
Use of Inflammatory Biomarkers to Guide Antibiotic Therapy in Patients With Severe Infections
NCT00934011 ·Status: COMPLETED ·Phase: NA
-
Beta-Lactam Antibiotics InitiaL ExpoSure OptimisEd in CriticallY Ill Patients with SEpsis
NCT06766461 ·Status: RECRUITING ·Phase: PHASE4
-
CRP Versus PCT as Bio-markers for Sepsis and in Guiding Antibiotics in Critically Ill Patients
NCT04049565 ·Status: COMPLETED
-
Bacterial Infection Diagnosis Using Blood DNA
NCT00698919 ·Status: UNKNOWN
-
Blood Culture Improvement Guidelines and Diagnostic Stewardship for Antibiotic Reduction in Critically Ill Children
NCT03441126 ·Status: COMPLETED
-
PCT and Clinical Algorithm for Determination of Duration of Antibiotics
NCT01572831 ·Status: COMPLETED ·Phase: PHASE3
-
Early Optimization of Ceftazidime Regimen in Critical Care
NCT07085624 ·Status: NOT_YET_RECRUITING ·Phase: NA
-
Safety and Efficacy of Procalcitonin Guided Antibiotic Therapy in Adult Intensive Care Units (ICU's)
NCT01139489 ·Status: COMPLETED ·Phase: NA
-
Prolonged Intravenous Infusion of β-lactam Antibiotics in Early Septic Patients
NCT05024565 ·Status: UNKNOWN ·Phase: NA
-
Impact of a Procalcitonin Testing and Treatment Algorithm on Antibiotic Use and Outcomes in the Pediatric Intensive Care Unit
NCT03440918 ·Status: COMPLETED ·Phase: NA
-
Clinical Outcomes and Inflammatory Responses in Viral vs. Bacterial Sepsis
NCT06491966 ·Status: RECRUITING
-
Procalcitonin to Guide Antibiotic Stop in Neurocritical Care Patients.
NCT03683693 ·Status: UNKNOWN ·Phase: NA
-
Pharmacokinetic/Pharmacodynamic Evaluation Amikacin in Critically Ill Patients Admitted at the Emergency Department
NCT02365272 ·Status: COMPLETED ·Phase: PHASE4
-
Resuscitation Failure, Oxidative Stress, and Necroptosis as Mortality Predictor in Septic Patient
NCT04169412 ·Status: COMPLETED
-
Procalcitonin Guided Versus Conventional Antibiotic Therapy in Patients With Sepsis in the ICU
NCT00987818 ·Status: WITHDRAWN ·Phase: NA
-
Immune Profile of Patients With Sepsis
NCT04163705 ·Status: UNKNOWN
-
Clinical Outcome Study of High-dose Meropenem in Sepsis and Septic Shock Patients
NCT03344627 ·Status: COMPLETED ·Phase: NA
-
mNGS vs Culture Critically Ill Patients
NCT03760315 ·Status: UNKNOWN
-
CD64 and Antibiotics in Human Sepsis
NCT02922998 ·Status: COMPLETED
-
Antibiotic Administration and Blood Culture Positivity in Severe Sepsis and Septic Shock
NCT01867905 ·Status: COMPLETED
-
Early Procalcitonin Kinetics During Empirical Antibiotic Therapy in Critically Ill Patients
NCT02294695 ·Status: COMPLETED
-
Pharmacokinetics of XueBiJing in Patients With Sepsis
NCT03475732 ·Status: COMPLETED ·Phase: NA