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Validation of a NICS Method Using the Culture Medium

NCT03879265 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2020-08-10

No results posted yet for this study

Summary

This study aims to validate a non-invasive method of chromosomal screening (NICS), based on the Multiple Annealing and Looping Based Amplification Cycles- Next-generation Sequencing (MALBAC-NGS) technology, in order to determine the chromosomal endowment of a blastocyst from the DNA of the embryonic culture medium.

The chromosomal status of the embryo from an embryo biopsy of trophoectoderm will be established (usual clinical practice), the chromosomal endowment from the DNA of the embryonic culture medium will be determined, and the results using the NICS and the conventional invasive method (Preimplantation Genetic Testing for Aneuploidy \[PGT-A\]) will be compared.

Conditions

  • Chromosome Abnormality
  • Abnormality

Interventions

DIAGNOSTIC_TEST

Noninvasive chromosome screening

Screening based on MALBAC-NGS technology

Sponsors & Collaborators

  • Instituto Bernabeu

    lead OTHER

Principal Investigators

  • Belén Lledo, PhD · Instituto Bernabeu

Eligibility

Min Age
19 Years
Max Age
49 Years
Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-02-01
Primary Completion
2019-12-01
Completion
2020-01-20

Countries

  • Spain

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03879265 on ClinicalTrials.gov