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Identification of Viable Human Embryos Using Three Different Methods

NCT01139268 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 161

Last updated 2013-07-18

No results posted yet for this study

Summary

Infertility affects an increasing number of couples. For many, the choice of treatment is in vitro fertilization (IVF) . Currently, there are no markers fully predictive of developmental competence of IVF embryos. Present embryo selection is based on morphology assessment, which produces implantation rates in the range of 20%-30 %. The overall purpose of the present study is to investigate methods for selection of the best embryo. We aim to examine the relationship between pregnancy outcome and the transcriptional profile of selected genes, cleavage kinetics (time-lapse), and metabolic profile. We hypothesise that the quality of the embryo is reflected by the transcription of selected genes, the cleavage kinetics, and the metabolic profile. If so, these parameters can predict the success or failure of a pregnancy. Furthermore, the interrelationship - if any - between these parameters will be evaluated.

A secondary aim is to evaluate the effect of blastomere biopsy using time-lapse and metabolic analysis

Conditions

Sponsors & Collaborators

  • University of Aarhus

    lead OTHER

Principal Investigators

  • Jakob Ingerslev, MD, DMsc · Fertility Clinic, Aarhus University Hospital, Skejby

  • kirstine Kirkegaard, MD · Fertility Clinic, Aarhus University Hospital, Skejby

  • Johnny Hindkjær, DM.Sc. · Fertility Clinic, Aarhus University Hospital, Skejby

  • Birte Degn, DmSc. PhD · Fertility Clinic, Aarhus University Hospital, Skejby

  • Karin Lykke-Hartmann, DmSc, PhD · Aarhus University, Department of Medical Biochemistry

  • Steen Koelvraa, MD, DMSc · Department of Clinical Genetics, Vejle Hospital

Eligibility

Min Age
18 Years
Max Age
37 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2010-06-30
Primary Completion
2013-06-30
Completion
2013-06-30

Countries

  • Denmark

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01139268 on ClinicalTrials.gov