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Minipuberty and Its Effects on Preterm Neonates

NCT03858127 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 20

Last updated 2019-03-07

No results posted yet for this study

Summary

It is generally known that there are some hormonal changes during puberty, but the knowledge about the activation of the same hormonal axis in the first months of life is relatively recent and it is not completely understood.

From the first weeks of life there is a progressive increase in hormone levels and this post-natal activation is called "minipuberty". Particularly in males, testosterone and androgen levels are associated with development and maturation of the reproductive system as well as changes in the brain structure and behaviours. Recently, it has also been suggested that the increasing testosterone level during the first 6 months of life, as well as during puberty, translates into an increase of linear growth.

In preterm neonates these hormones rise higher and for longer than in full-term newborns, suggesting that its activity is evolutionarily regulated.

With this study researchers would like to investigate these changes and correlate hormone levels with linear growth and neurobehavioral development of preterm infants.

Conditions

  • Infant, Newborn

Interventions

OTHER

Collection of urine sample

Collection of urine sample for measurement of LH and FSH

OTHER

Examination of genitalia

Examination of genitalia

OTHER

Video messaging

Short video of infant recorded at home by the parents

Sponsors & Collaborators

  • NHS Greater Glasgow and Clyde

    lead OTHER

Principal Investigators

  • Paul Dearie · NHS GGC R&D

Eligibility

Max Age
72 Hours
Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-03-31
Primary Completion
2020-08-31
Completion
2020-08-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03858127 on ClinicalTrials.gov