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High Altitude and Exogenous Carbohydrate Oxidation

NCT03851744 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 10

Last updated 2021-09-02

Study results available
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Summary

Recent studies have reported that oxidation of exogenous carbohydrate is reduced under acute hypobaric hypoxic (high altitude; HA) conditions compared to normoxia (sea level; SL) in native lowlanders. However, the mechanisms by which HA suppresses exogenous carbohydrate oxidation are not known. This study will seek to confirm that acute HA exposure decreases exogenous carbohydrate oxidation during steady-state aerobic exercise compared to SL, and explore if the mechanism inhibiting plasma glucose uptake is insulin dependent or independent.

Conditions

  • Glucose Metabolism
  • High Altitude

Interventions

OTHER

Sea Level

Carbohydrate consumed at 1.8 g/min during treadmill exercise at SL

OTHER

High Altitude

Carbohydrate consumed at 1.8 g/min during treadmill exercise at HA

Sponsors & Collaborators

  • University of Arkansas

    collaborator OTHER

  • United States Army Research Institute of Environmental Medicine

    lead FED

Principal Investigators

  • Lee M Margolis, PhD · Military Nutrition Division, USARIEM

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
39 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-11-28
Primary Completion
2019-11-01
Completion
2020-09-01

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03851744 on ClinicalTrials.gov