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Pacing in Left Ventricular Assist Device Recipients

NCT03844516 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 15

Last updated 2020-06-02

No results posted yet for this study

Summary

Implantation with left ventricular assist device (LVAD) in patients with end-stage heart failure (HF) leads to improvements in survival and quality of life, however, work capacity remains disappointingly low, at half of the expected value. Complex central and peripheral hallmarks of heart failure attribute to the continued work intolerance, to which heart rate may be a contributing factor.

The purpose of this study is to clarify the impact of heart rate (by means of pacing) on work capacity (measured as peak oxygen uptake) in LVAD recipients.

Conditions

  • Heart Rate
  • Chronotropic Incompetence
  • Pacing

Interventions

OTHER

Peak oxygen uptake test with pacing

Peak oxygen uptake test with paced heart rate

OTHER

Peak oxygen uptake test without pacing

Peak oxygen uptake test without paced heart rate

Sponsors & Collaborators

  • Finn Gustafsson

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-04-23
Primary Completion
2021-01-31
Completion
2021-01-31

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03844516 on ClinicalTrials.gov