Early Double Sequential Defibrillation in Out-of-hospital Cardiac Arrest

Summary

Some of the patients affected by Out-of-hospital cardiac arrest (OHCA) with ventricular fibrillation (VF)/ventricular tachycardia (VT) do not respond to initial defibrillation. The survival decreases with number of defibrillations required to terminate VF/VT. In 2022, one prospective cluster randomized trial showed increased survival among (OHCA) patients in refractory VF using Double Sequential Defibrillation (DSD).

To evaluate feasibility and safety this randomized pilot trial will compare the effect of double defibrillation strategy initiated as soon as possible after the first defibrillation with continued resuscitation using standard defibrillation, in patients with Out of Hospital Cardiac arrest (OHCA). The results from this pilot trial will form the basis for design of a larger multicenter survival study.

Conditions

• Cardiac Arrest
• Fibrillation, Ventricular
• Sudden Cardiac Death
• Sudden Cardiac Arrest

Interventions

DEVICE

Double Sequential Defibrillation (DSD)

The second defibrillator will be applyed with electrodes placed in the A-P position

DEVICE

Standard defibrillation

Standard defibrillation uning one defibrillator

Sponsors & Collaborators

• Karolinska Institutet

  lead OTHER

Principal Investigators

• Gabriel Riva, MD, PhD · Karolinska Institutet

• Akil Awad, MD, PhD · Karolinska Institutet

• Andreas Claesson, RN, PhD · Karolinska Institutet

• Carl Magnusson, RN, PhD · Sahlgrenska University

• Leif Svensson, MD, PhD · Karolinska Institutet

• Johan Israelsson, RN, PhD · Linné University

• Emma Blick-Nordqvist, MD · Karolinska Institutet

• Martin Jonsson, Msc, PhD · Karolinska Institutet

• Jacob Hollenberg, MD, PhD · Karolinska Institutet

• Sheldon Cheskes, MD · University of Toronto

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2024-08-01

Primary Completion

2025-05-31

Completion

2025-09-23

Countries

• Sweden

Study Locations