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Muscle Recovery After Critical Illness

NCT05537298 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 209

Last updated 2025-11-24

No results posted yet for this study

Summary

The overarching goal of the proposed study is to determine the trajectories of physical recovery and cellular markers involved with the underlying failure to recover muscle after critical illness, while exploring which characteristics are associated with sustained physical disability. This proposal will examine muscle pathophysiology carefully aligned with physical function outcomes in order to longitudinally assess the recovery, or failed recovery, of muscle function in participants after critical illness:

1. to examine the recovery of muscle and physical function in ICU survivors through longitudinal assessments
2. to investigate the underlying cellular markers and mechanisms of muscle recovery in ICU survivors
3. to determine which cellular markers contribute to physical disability in ICU survivors up to 1 year after hospital admission

Conditions

  • ICU Acquired Weakness
  • Post Intensive Care Unit Syndrome
  • Muscle Weakness
  • Critical Illness

Sponsors & Collaborators

  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

    collaborator NIH

  • Oklahoma Medical Research Foundation

    collaborator OTHER

  • University of Alabama at Birmingham

    collaborator OTHER

  • Kirby Mayer

    lead OTHER

Principal Investigators

  • Kirby P Mayer, PhD · University of Kentucky

Eligibility

Min Age
18 Years
Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-10-18
Primary Completion
2027-07-02
Completion
2027-08-01

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05537298 on ClinicalTrials.gov