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Phenotypic and Functional Study of 4BL B Cells in Multiple Sclerosis (MS)

NCT03796611 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 125

Last updated 2026-05-05

No results posted yet for this study

Summary

Recent works highlight the B cells involvement in multiple sclerosis (MS) pathology but their role remains poorly understood. It was previously described that activated memory B cells called 4BL due to the increased expression of 4-1BBL, an activation marker, induce pro-inflammatory response by activating T CD8+ lymphocytes. Those 4BL cells are also described in systemic inflammation in 80 years old people explaining the poor efficiency of vaccination in that sub population. Those 4BL cells can also induce anti-tumoral T cell response.

The hypothesize is that 4BL may induce a pathogenic inflammatory response in MS.

Conditions

Sponsors & Collaborators

  • University Hospital, Lille

    lead OTHER

Principal Investigators

  • Hélène ZEPHIR, MD, PhD · University Hospital, Lille

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-07-24
Primary Completion
2017-08-24
Completion
2017-08-24

Countries

  • France

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03796611 on ClinicalTrials.gov