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An Observational Study to Investigate the Role of B Cells in Multiple Sclerosis

NCT04964336 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 40

Last updated 2021-07-16

No results posted yet for this study

Summary

Multiple sclerosis (MS) typically afflict young people in their twenties, when they start a career and establish a family. The disease thus imposes a severe impact on quality of life and heavy economic burdens on society. Critical barriers to progress in the field are the lack of knowledge of relevant immune cell subsets driving the pathology and the targets of the immune response within the central nervous system. In this project, we will test the hypothesis that a subgroup of MS patients is defined by a genetically determined B cell response against specific antigenic epitopes. The hypothesis is based on our recent, pioneering results showing that approximately half of MS patients have a restricted population of B cells in the cerebrospinal fluid defined by polymorphisms in the constant heavy-chain of the immunoglobulin B cell receptor, the G1m1 allotype. Here, we aim to characterize the G1m1 B cells, to disentangle the genetic basis of the B cell response, and to identify the molecular targets.

Conditions

Interventions

OTHER

Analysis of B cells

B cells from blood and cerebrospinal fluid will be analyzed using RNA-seq

Sponsors & Collaborators

  • University of Oslo

    lead OTHER

Principal Investigators

  • Andreas Lossius · University of Oslo

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-02-05
Primary Completion
2024-12-31
Completion
2024-12-31

Countries

  • Norway

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04964336 on ClinicalTrials.gov