End stage renal disease (ESRD), also called end stage kidney disease, is kidney failure requiring dialysis or kidney transplantation for survival. It is the terminal stage of chronic kidney disease and carries high morbidity and mortality. The condition imposes substantial long-term healthcare burden.
A multicenter retrospective cohort study of 17 patients with type 2 diabetes and end-stage renal disease found injectable semaglutide was associated with descriptive changes in glycemic control and body weight. No cardiovascular deaths, nonfatal myocardial infarctions, or nonfatal strokes were observed during follow-up.
The FDA is set to make decisions on four drug applications in April 2026, including Orca-T for hematological malignancies, orforglipron for obesity, sparsentan for kidney disease, and a doravirine/islatravir combination for HIV-1.
The FDA has approved pitolisant tablets for treating cataplexy in pediatric patients aged 6 and older with narcolepsy, making it the only non-scheduled therapy approved for both pediatric and adult narcolepsy patients with or without cataplexy.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07591714 |
The Effect of Intradialytic Eye Exercise in Hemodialysis Patients |
NOT_YET_RECRUITING | NA |
| NCT07364292 |
Shared Decision Making in Dialysis Modality Selection: a Lived Experience From Nephrologists. A Nationwide Qualitative Study. |
COMPLETED | NA |
| NCT07360938 |
Drug Interaction Potential of Pro-Inflammatory Conditions |
RECRUITING | |
| NCT07216885 |
Solv Multi-Pass Hemodialysis System In-Center Clinical Study |
RECRUITING | NA |
| NCT07058909 |
Premarket Clinical Safety Assessment of the ELISIO™-HX |
COMPLETED | NA |
| NCT07020832 |
A Phase 3 Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Adults at High Risk of Delayed Graft Function (DGF) Following Kidney Allograft Transplantation |
RECRUITING | PHASE3 |
| NCT06861816 |
Ventilatory Functions and Physical Intolerance in ESRD Adolescents: Response to Program of Walking With Dogs |
RECRUITING | NA |
| NCT06787599 |
The Effect of Home Based Tele-Exercise on Peritoneal Dialysis Patients |
COMPLETED | NA |
| NCT06765577 |
Prognostic Value of Finger Blood Pressure in Arteriovenous Fistula Care |
COMPLETED | NA |
| NCT06650215 |
The 2-minute Walk Test in Hemodialysis Patients |
NOT_YET_RECRUITING |
