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Viscoelastic Tests-Guided Therapy In Liver Transplantation

NCT03756948 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 237

Last updated 2018-11-28

No results posted yet for this study

Summary

BACKGROUND: Perioperative bleeding and transfusion are important causes of morbidity and mortality in patients undergoing liver transplantation. The aim of this study is to assess whether viscoelastic tests-guided therapy with the use of synthetic factor concentrates impact transfusion rates of hemocomponents in adult patients undergoing liver transplantation.

METHODS: This is an interventional before-after comparative study. Patients undergoing liver transplantation before the implementation of a protocol using thromboelastometry and synthetic factor concentrates were compared to patients after the implementation. Primary outcome was transfusion of any hemocomponents. Secondary outcomes included: transfusion of red blood cells (RBC), fresh frozen plasma (FFP), cryoprecipitate or platelets, clinical complications, length of stay and in-hospital mortality.

Conditions

  • Liver Transplant; Complications
  • Bleeding
  • Hemostatic Disorder

Interventions

OTHER

Usual Care

Treatment of Coagulation Disorders Using Standard Coagulation Tests and Blood Components

OTHER

Thromboelastometry-Guided Therapy with Synthetic Factor Concentrates

Thromboelastometry-Guided Treatment of Coagulation Disorders Using Synthetic Factor Concentrates

Sponsors & Collaborators

  • Hospital Israelita Albert Einstein

    lead OTHER

Principal Investigators

  • Ary Serpa Neto, MD, MSc, PhD · Physician and Researcher

  • Raffael PC Zamper, MD · Raffael

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
SEQUENTIAL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2007-01-01
Primary Completion
2015-10-30
Completion
2018-01-01

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Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03756948 on ClinicalTrials.gov