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Thrombin Generation in Liver Transplant Surgery

NCT04762550 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2021-05-03

No results posted yet for this study

Summary

This is a prospective observational study of 100 patients undergoing liver transplantation at a single centre. Thrombin generation and kinetics will be assessed using a novel point-of-care device, and compared to conventional measures of hemostasis as well as viscoelastic tests to pinpoint specific coagulation deficits and identify potential therapeutic targets. The clinical course of patients will be followed for major bleeding and transfusion outcomes.

Conditions

  • Liver Transplantation
  • Thrombin
  • Hemostasis, Surgical
  • Blood Coagulation Disorder Due to Liver Disease
  • Blood Coagulation Disorders

Sponsors & Collaborators

  • University Health Network, Toronto

    lead OTHER

Principal Investigators

  • Justyna Bartoszko, MD MSc FRCPC · Toronto General Hospital - University Health Network

  • Keyvan Karkouti, MD MSc FRCPC · Toronto General Hospital - University Health Network

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-03-08
Primary Completion
2022-01-01
Completion
2022-01-01

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04762550 on ClinicalTrials.gov