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Upper Limit for TSH of First and Second Trimester Pregnancy in Turkey

NCT03754621 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 400

Last updated 2019-04-23

No results posted yet for this study

Summary

Physiological changes necessitate the use of pregnancy-specific reference ranges for TSH and FT4 to diagnose thyroid dysfunction during pregnancy. Although many centers use fixed upper limits for TSH of 2.5 or 3.0 mU/L, this may lead to overdiagnosis or even overtreatment.

The new guidelines of the American Thyroid Association have considerably changed recommendations regarding thyroid function reference ranges in pregnancy accordingly. Any hospital or physician that is still using the 2.5 or 3.0 mU/l cut-off for TSH during pregnancy should evaluate their own lab-specific cut-offs.

The investigator's objective is to establish a rational reference range of serum TSH for diagnosis of subclinical hypothyroidism in the first and second trimester of pregnant women in west Black Sea region in Turkey.

Conditions

Interventions

DIAGNOSTIC_TEST

Serum thyroid functions tests

Serum TSH, fT3, fT4 and anti-TPO

Sponsors & Collaborators

  • Bartin State Hospital

    lead OTHER_GOV

Principal Investigators

  • Murat Yassa, MD · Bartin State Hospital

Eligibility

Min Age
18 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-10-15
Primary Completion
2019-07-02
Completion
2019-07-15

Countries

  • Turkey (Türkiye)

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03754621 on ClinicalTrials.gov