MedTrace Logo

Correlation Between Levothyroxine and Blood Th17/Treg in Pregnant Women With Normal-high TSH and Positive TPOAb

NCT06527859 · Status: TERMINATED · Type: OBSERVATIONAL · Enrollment: 64

Last updated 2024-07-30

No results posted yet for this study

Summary

The purpose of this clinical trial is to understand the impact of different doses of levothyroxine on the immune inflammatory response in pregnant women with normal-high TSH and positive TPOAb in the first half of pregnancy. It aims to answer the main questions:

Are there differences in immune inflammation between normal pregnant women and those in the disease group? Can different doses of levothyroxine improve the Th17/Treg ratio and cytokine levels in the disease group? Researchers first compared the differences between normal pregnant women and those in the disease group, and then administered two different doses of levothyroxine to the disease group to observe whether different doses of levothyroxine can improve the immune inflammation in this group.

pregnant women in the disease group will: Take the same dose of levothyroxine (25/50ug) every day Return for a follow-up visit after 4 weeks of medication

Conditions

  • Pregnancy Related
  • Thyroid Stimulating; Hormone, C

Interventions

DRUG

Levothyroxin

The disease group were divided into two groups ,25ugLT4 (HA group, n=17) and 50ugLT4 (HB group, n=17) respectively.

Sponsors & Collaborators

  • Third Affiliated Hospital of Zhengzhou University

    lead OTHER

Principal Investigators

  • Xin Tian · Third Affiliated Hospital of Zhengzhou University

  • Yanjie Ban · Third Affiliated Hospital of Zhengzhou University

Eligibility

Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-04-06
Primary Completion
2023-10-31
Completion
2024-06-05

Countries

  • China

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06527859 on ClinicalTrials.gov