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Exercise and Coronary Heart Disease Risk Markers in Male Smokers and Non-Smokers

NCT03735186 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 24

Last updated 2018-11-09

No results posted yet for this study

Summary

The present study will investigate the effect of acute exercise on fasting and postprandial risk markers for coronary heart disease (CHD) in healthy male cigarette smokers and non-smokers.

Participants will complete two, 2-day trials in a random crossover design separated by an interval of at least 1 week. On day 1, participants will rest (control) or complete 60 minute of treadmill exercise at 60% of maximum oxygen uptake (exercise). On day 2, participants will rest and consume two high fat meals (breakfast and lunch) over an 8-h period during which 13 venous blood samples and nine blood pressure measurements will be taken at pre-determined intervals.

It is hypothesised that men who smoke cigarettes will exhibit impaired fasting and postprandial metabolic risk markers compared to non-smokers, but a single bout of exercise will be equally, if not more, efficacious for improving the CHD risk factor profile in smokers than non-smokers.

Conditions

Interventions

BEHAVIORAL

Exercise

60 min treadmill exercise performed at 60% of maximum oxygen uptake.

Sponsors & Collaborators

  • University of Leicester

    collaborator OTHER

  • University Hospitals, Leicester

    collaborator OTHER

  • Loughborough University

    lead OTHER

Principal Investigators

  • David Stensel · Loughborough University

  • Tareq Alotaibi · Loughborough University

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
20 Years
Max Age
45 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-08-04
Primary Completion
2018-10-02
Completion
2018-10-02

Countries

  • United Kingdom

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03735186 on ClinicalTrials.gov