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Predictors for Analgesic Effect to Standardized Exercise Therapy for Osteoarthritic Pain

NCT03718663 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 28

Last updated 2019-07-05

No results posted yet for this study

Summary

Pain sensitization has been associated with pain severity in people with knee osteoarthritis (KOA) and a neuropathic pain component has been identified in up to 30% of KOA patients. In addition, exercise-induced hypoalgesia (EIH), a measure of descending pain control, has previously been found dysfunctional in a subgroup of people with painful KOA and has also been utilized as a predictive factor for pain progression following total knee replacement.

Measures of pain sensitization have been used prognostic to identify responders to treatment but EIH as a prognostic tool for Physiotherapy-guided Evidence-based Exercise Therapy (PEET) has not been investigated. The primary aim of this explorative study is to investigate if EIH assessed pre-PEET was associated with changes in pain, disability and PainDETECT (PDQ) score post-PEET. The secondary aim is to investigate if PEET changes EIH and PDQ score in patients with painful KOA.

Part 2:

Cross-sectional studies indicate, that daily level of activity influence the effectivity of the EIH mechanims, while pain patients (e.g. KOA patients) can have normal of dysfunctional EIH. It has not been investigated if EIH changes after prolonged exercise in healthy subjects. The aim of this secord part of the study, is to investigate if EIH changes after 6-9 weeks of intensive military training in healthy subjects

Conditions

  • Osteoarthritis, Knee
  • Healthy Subjects

Interventions

OTHER

Physiotherapy-guided Evidence-based Exercise Therapy

Standardized supervised exercise therapy for 6-8 weeks (two times per week).

OTHER

Part 2: Military training

Part 2: standardized military training for 6-8 weeks in Defence Command Denmark

Sponsors & Collaborators

  • Kristian Kjær Petersen

    lead OTHER

Principal Investigators

  • Kristian K Petersen, PhD · Aalborg University

Eligibility

Min Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-10-01
Primary Completion
2018-10-31
Completion
2018-11-01

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03718663 on ClinicalTrials.gov