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Comparing the Digestion of Milk With Different Beta-casein Protein Content by Dairy Intolerant Persons

NCT03713346 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 42

Last updated 2021-10-08

No results posted yet for this study

Summary

Persons with dairy intolerance may experience cramps/abdominal pain, bloating, flatulence, acute diarrhea, or fecal urgency when they ingest excessive amounts of lactose. The intensity of these conditions can be mild or severe and likely depends on numerous variables including dose, transit time, intestinal residual lactase activity and microbiome potential to ferment lactose. Jersey cattle produce milk containing high levels of the A2 β-casein protein . There are claims that high A2 β-casein milk is more easily digested by people who are lactose maldigesters . We propose to conduct a double-blinded, randomized, controlled trial to determine if high A2 β-casein milk from Jersey cattle is actually better digested and tolerated by lactose maldigesters.

Conditions

  • Dairy Intolerance

Interventions

OTHER

Lactose free milk

Single dose of lactose free milk

OTHER

Jersey milk

Single dose of jersey milk

OTHER

High A1 β-casein milk

Single dose of high A1 β-casein milk (commercial milk)

OTHER

High A2 β-casein milk

Single dose of A2 β-casein milk

Sponsors & Collaborators

  • Purdue University

    lead OTHER

Principal Investigators

  • Dennis A Savaiano, PhD · Purdue University

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-01-17
Primary Completion
2021-09-03
Completion
2021-09-03

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03713346 on ClinicalTrials.gov