Effects of A2 Milk on Gastrointestinal Function in Non-lactose Milk Intolerance

Summary

There is increasing evidence that a number of people experience moderate milk intolerance characterised by increased gas production, bloating and abdominal cramp, which can neither be attributed to lactose intolerance, nor to milk protein allergy. Milk digestion can lead to the formation of bioactive peptides, one of which derived from a mutated gene variant (A1) coding for milk beta-casein has been associated with increased gastrointestinal inflammation and poor gastrointestinal function. In this study, we hypothesise that consumption of non-mutated A2 milk will improve gastrointestinal symptoms in non-lactose milk intolerant individuals.

Conditions

• Milk Intolerance

Interventions

DIETARY_SUPPLEMENT

A2 milk 100

Days 1 and 2: 100 mL A2 milk twice a day

DIETARY_SUPPLEMENT

A2 milk 150

Days 3 and 4: 150 mL A2 milk twice a day

DIETARY_SUPPLEMENT

A2 milk 200

Days 5 and 6: 200 mL A2 milk twice a day

DIETARY_SUPPLEMENT

A2 milk 250

Days 7 to 14: 250 mL A2 milk twice a day

DIETARY_SUPPLEMENT

A1/A2 milk 100

Days 1 and 2: 100 mL A1/A2 milk twice a day

DIETARY_SUPPLEMENT

A1/A2 milk 150

Days 3 and 4: 150 mL A1/A2 milk twice a day

DIETARY_SUPPLEMENT

A1/A2 milk 200

Days 5 and 6: 200 mL A1/A2 milk twice a day

DIETARY_SUPPLEMENT

A1/A2 milk 250

Days 7 to14: 250 mL A1/A2 milk twice a day

Sponsors & Collaborators

• University of Reading

  lead OTHER

Principal Investigators

• Sandrine P Claus, PhD · University of Reading

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

QUADRUPLE

Model

CROSSOVER

Eligibility

Min Age

18 Years

Max Age

56 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2017-04-01

Primary Completion

2018-04-30

Completion

2019-03-31

Countries

• United Kingdom

Study Locations