Internet Based Cognitive Behavioral Therapy in Pediatric Chronic Pancreatitis

Summary

Abdominal pain is common in children with chronic and acute recurring pancreatitis (CP, ARP), and as they continue into adulthood, the disease progresses with increased pain and greater exposure to opioids. Despite the relevancy of early pain self-management for childhood pancreatitis, there have been no studies of non-pharmacological pain intervention in this population. The proposed project will evaluate a web-based cognitive behavioral pain management program delivered to a cohort of well-phenotyped children with CP/ARP and some community participants to reduce pain, pain-related disability and enhance HRQOL; it will also identify genetic risk factors and clinical and behavioral phenotypic factors associated with treatment response to enable precision medicine approaches.

Conditions

• Chronic Pancreatitis
• Acute Recurrent Pancreatitis

Interventions

BEHAVIORAL

Web-based CBT

The eight child modules include: 1) education about chronic pain, 2) recognizing stress and negative emotions, 3) deep breathing and relaxation, 4) implementing coping skills at school, 5) cognitive skills (e.g., reducing negative thoughts), 6) lifestyle interventions, 7) staying active (e.g., pleasant activity scheduling), 8) relapse prevention. The eight parent modules are: 1) education about chronic pain, 2) recognizing stress and negative emotions, 3) operant strategies I (using attention and praise to increase coping), 4) operant strategies II (using rewards to increase positive coping and reach school goals), 5) modeling, 6) lifestyle, 7) communication, 8) relapse prevention.

BEHAVIORAL

Pain Education

The pain education website provides publicly available educational information about pancreatitis and abdominal pain. There is general information about pancreatitis from available web sources (e.g., National Pancreas Foundation) as well as information about chronic pain in childhood. The content does not include any instruction in the behavioral and cognitive skills taught within the WebMAP program.

Sponsors & Collaborators

• University of Iowa

  collaborator OTHER

• University of Virginia

  collaborator OTHER

• Washington University School of Medicine

  collaborator OTHER

• M.D. Anderson Cancer Center

  collaborator OTHER

• The University of Texas Health Science Center, Houston

  collaborator OTHER

• Children's Hospital Medical Center, Cincinnati

  collaborator OTHER

• Children's Hospital Los Angeles

  collaborator OTHER

• Children's Hospital of Philadelphia

  collaborator OTHER

• University of Toronto

  collaborator OTHER

• McGill University Health Centre/Research Institute of the McGill University Health Centre

  collaborator OTHER

• Medical College of Wisconsin

  collaborator OTHER

• Massachusetts General Hospital

  collaborator OTHER

• University of Minnesota

  collaborator OTHER

• Ohio State University

  collaborator OTHER

• University of Pittsburgh

  collaborator OTHER

• University of California, San Francisco

  collaborator OTHER

• University of Utah

  collaborator OTHER

• Indiana University

  collaborator OTHER

• Sydney Children's Hospitals Network

  collaborator OTHER

• Cedars-Sinai Medical Center

  collaborator OTHER

• Stanford University

  collaborator OTHER

• Ariel Precision Medicine

  collaborator INDUSTRY

• University of Texas Southwestern Medical Center

  collaborator OTHER

• Seattle Children's Hospital

  lead OTHER

Principal Investigators

• Tonya Palermo, PhD · Seattle Children's Hospital

• Aliye Uc, MD · University of Iowa

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Model

PARALLEL

Eligibility

Min Age

10 Years

Max Age

19 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2019-04-25

Primary Completion

2024-07-31

Completion

2024-07-31

Countries

• United States

Study Locations