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Comparative Evaluation of the Regenerative Capacity of Two Platelet Concentrates

NCT03698188 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 24

Last updated 2018-10-25

No results posted yet for this study

Summary

Injectable platelet-rich fibrin (I-PRF) is a flowable blood concentrate that is entirely natural and allows ease of access and flow within the root canal. It was first developed in 2014 by modifying the centrifugation parameters. I-PRF has great potential in the field of endodontics. At present, it is still in its infancy and needs to be explored with regard to its regenerative efficacy.

To the best of our knowledge, this study is the first to clinically and comparatively investigate Platelet-rich plasma (PRP) and I-PRF.

Conditions

  • Necrotic Pulp

Interventions

PROCEDURE

Injectable platelet-rich fibrin

A blood sample will be drawn from the patient, centrifuged at 700 rpm for 3 minutes and the upper yellow fluid will be collected by a plastic syringe, avoiding the inclusion of the red blood cells underneath, and will be introduced within the root canal.

PROCEDURE

Platelet-rich plasma

A blood sample will be drawn from the patient, centrifuged at 3000 rpm for 10 minutes and the upper yellow fluid will be collected by a plastic syringe, avoiding the inclusion of the red blood cells underneath, and will be introduced within the root canal.

Sponsors & Collaborators

  • Cairo University

    lead OTHER

Principal Investigators

  • Jealane El-Shafei, PhD · Professor Doctor of Endodontics, Faculty of Dentistry, Cairo University.

  • Samia Shouman, PhD · Professor Doctor of Medical Biochemistry, National Cancer Institute, Cairo University

  • Nehal Nabil, PhD · Lecturer of Endodontics, Faculty of Dentistry, Cairo University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
10 Years
Max Age
25 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-11-30
Primary Completion
2019-05-31
Completion
2020-05-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03698188 on ClinicalTrials.gov