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Epicardial Fat in Coronary Artery Disease

NCT03693261 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 43

Last updated 2019-04-17

No results posted yet for this study

Summary

We hypothesize that human epicardial fat plays a thermogenic role to the myocardium. We hypothesize that epicardial fat may express genes of brown fat and thyroid function that are down-regulated by the presence of coronary artery disease. Because the postulated metabolic role of the epicardial fat, we also hypothesize that the gene expression of these regulatory thermogenic factors is higher in epicardial than subcutaneous fat

This will be a cross-sectional study conducted over a one-year period in patients with or without coronary artery disease who require elective cardiac surgery regardless their participation in the study.

Study group will be formed by 50 patients with clinically and angiographically established CAD who will undergo coronary artery bypass graft, as part of their standard medical care. Control group will be formed by 10 subjects, randomly selected, who will undergo cardiac surgery for aortic or mitral valve replacement as part of their standard medical care (these patients have no history, clinical signs of CAD, and show normal coronary arteries on coronary angiography).

This will be a cross-sectional study conducted over a one-year period in patients with or without coronary artery disease who require elective cardiac surgery regardless their participation in the study.

Adipose tissue will be collected during the cardiac surgery.

Conditions

Interventions

PROCEDURE

Coronary artery bypass grafting (CABG)

CABG, as part of the standard medical care

PROCEDURE

Valve replacement

cardiac surgery for aortic or mitral valve replacement as part of their standard medical care

Sponsors & Collaborators

  • University of Miami

    lead OTHER

Eligibility

Min Age
50 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2011-12-18
Primary Completion
2019-04-15
Completion
2019-04-15

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03693261 on ClinicalTrials.gov