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Ghrelin and Diastolic Heart Function

NCT05988346 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 60

Last updated 2023-08-24

No results posted yet for this study

Summary

In type 2 diabetes mellitus (T2DM) and obese patients the adipose tissue could over-express cytokines, sirtuin-1 (SIRT1), and microRNAs (miRs) implied in the regulation of left ventricle (LV) diastolic function (LV-DF). Ghrelin could modulate these pathways. Thus, in the current study authors will investigate ghrelin expression in T2DM obese patients after abdominal fat excision, and particularly in those with normalization of LV-DF at 1 year of follow-up.

Conditions

  • Diabetes Mellitus, Type 2
  • Obesity, Abdominal
  • Diastolic Dysfunction

Interventions

PROCEDURE

abdominal plastic intervention

According to international guidelines, authors will remove the superficial abdominal fat from the patients enrolled in the study.

Sponsors & Collaborators

  • University of Campania Luigi Vanvitelli

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-01-01
Primary Completion
2022-01-01
Completion
2022-03-01

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05988346 on ClinicalTrials.gov