Comparison of Surgical and Medical Treatment for Congestive Heart Failure and Coronary Artery Disease

Summary

This study will compare medical therapy with coronary bypass surgery and/or surgical ventricular reconstruction for patients with congestive heart failure and coronary artery disease (CAD).

Conditions

• Cardiovascular Diseases
• Coronary Disease
• Heart Failure, Congestive
• Heart Diseases

Interventions

PROCEDURE

CABG surgery plus MED

CABG plus standard medication management for Coronary Artery Disease

DRUG

Active Medication Alone

Standard medication for coronary artery disease and heart failure management.

PROCEDURE

CABG plus MED and SVR

H02: the experimental arm receives active medical therapy and CABG and surgical ventricular restoration whereas the control group receives active medical therapy and CABG; for H01: the experimental arm receives active medical therapy and CABG whereas the control group receives active medical therapy alone

Sponsors & Collaborators

• National Heart, Lung, and Blood Institute (NHLBI)

  collaborator NIH

• Duke University

  lead OTHER

Principal Investigators

• Robert Bonow · Radionuclide Core Lab, Northwestern University

• Arthur Feldman · Neurohormonal Core Lab, Jefferson University

• Eric Velazquez, MD · Clinical Coordinating Center, Duke University

• Kerry Lee · Data Coordinating Center, Duke University

• Daniel Mark · Economics and Quality of Life Core Lab, Duke University

• Jae Oh · Echocardiographic Core Lab, Mayo Clinic

• Gerald Pohost · Magnetic Resonance Imaging Core Lab, University of Southern California

• Jean Rouleau · Université de Montréal

• Julio A Panza, MD · Medstar Health Research Institute

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

100 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2002-01-31

Primary Completion

2015-11-30

Completion

2015-11-30

Countries

• United States

Study Locations