Improving Medication Adherence in Adolescents Who Had a Liver Transplant

Summary

The study's aim is to test a tailored telemetric intervention to reduce rejection incidence by improving medication adherence in a group of adolescent liver transplant recipients identified as nonadherent by a marker (the Medication Level Variability Index, MLVI).

Conditions

• Transplant

Interventions

BEHAVIORAL

Telemetric Intervention

Calls, scripted by a manual; the frequency of the calls varies with patient's MLVI status and preferences.

Sponsors & Collaborators

• University of California, Los Angeles

  collaborator OTHER

• Ann & Robert H Lurie Children's Hospital of Chicago

  collaborator OTHER

• Baylor College of Medicine

  collaborator OTHER

• University of Pittsburgh

  collaborator OTHER

• University of California, San Francisco

  collaborator OTHER

• Children's Hospital of Michigan

  collaborator OTHER

• Children's Hospital of Philadelphia

  collaborator OTHER

• Emory-Children's Center

  collaborator OTHER

• The Hospital for Sick Children

  collaborator OTHER

• National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

  collaborator NIH

• Columbia University

  collaborator OTHER

• Seattle Children's Hospital

  collaborator OTHER

• University of Miami

  collaborator OTHER

• Children's Hospital Los Angeles

  collaborator OTHER

• Icahn School of Medicine at Mount Sinai

  lead OTHER

Principal Investigators

• Eyal Shemesh, MD · Icahn School of Medicine at Mount Sinai

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

12 Years

Max Age

19 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2018-11-14

Primary Completion

2025-10-22

Completion

2025-10-22

Countries

• United States
• Canada

Study Locations