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Microbiome in Lung Cancer and Other Malignancies

NCT03688347 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 44

Last updated 2022-05-11

No results posted yet for this study

Summary

To characterize the fecal, skin, nasal and oral microbiome and metabolome in patients with lung cancer and other malignancies, and correlate to treatment response and toxicities of various therapies including immunotherapy, chemotherapy and targeted therapy, etc.

Conditions

Interventions

PROCEDURE

Nasal Swab

The swab is removed from packaging, moistened with sterile water if needed to prevent any discomfort to the participant. The swab is gently inserted less than one inch into the anterior nare (nostril) until resistance is met at turbinate. Then it is rotated several times against nasal wall and repeated in other nostril using the same swab.

PROCEDURE

Oral Swab

The swab is removed from packaging, moistened with sterile water if needed to prevent any discomfort to the participant. The swab is gently rubbed along the inside of the participant's cheek for 5-10 seconds.

OTHER

Stool Collection

A stool collection kit will be sent home with each participant. It will include instructions on how to collect the stool specimen and how to return the kit.

GENETIC

Microbiome analysis

Study of microbial communities found in and on the human body.

GENETIC

DNA Banking

Secure, long term storage of an individual's genetic material.

PROCEDURE

Skin Swab

Gentle rubbing of the swab will be applied to the skin on the dorsal part of the hand.

Sponsors & Collaborators

  • Holden Comprehensive Cancer Center

    collaborator OTHER

  • Iowa Institute of Human Genetics

    collaborator UNKNOWN

  • Taher Abu Hejleh

    lead OTHER

Principal Investigators

  • Taher Abu Hejleh, MBBS · University of Iowa

Eligibility

Min Age
18 Years
Max Age
100 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-08-30
Primary Completion
2019-09-23
Completion
2022-05-09

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03688347 on ClinicalTrials.gov