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The Effect of Antioxidants on Skin Blood Flow During Local Heating

NCT03680638 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 44

Last updated 2018-09-21

No results posted yet for this study

Summary

The goal of this study is to examine possible mechanisms of impaired vasodilaton in obese and Black/African American men and women as possible links to the elevated prevalence of cardiovascular dysfunction and disease. The main targets in this study are sources of oxidative stress.

Conditions

Interventions

OTHER

Control (Lactated Ringer's)

This intervention is meant to serve as a control by which the experimental sites are compared to, to assess effectiveness.

DRUG

Tempol

This intervention is meant to assess the impact of superoxide on vasodilator responses by scavenging available superoxide.

DRUG

Apocynin

This intervention is meant to assess the impact of NADPH oxidase-derived superoxide on vasodilator responses by inhibiting the enzyme NADPH oxidase.

DRUG

Allopurinol

This intervention is meant to assess the impact of xanthine oxidase-derived superoxide on vasodilator responses by inhibiting the enzyme xanthine oxidase.

Sponsors & Collaborators

  • The University of Texas at Arlington

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-09-07
Primary Completion
2017-10-09
Completion
2017-10-09
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03680638 on ClinicalTrials.gov