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Pathogenic Mechanisms of Cancer and Cardiovascular Diseases

NCT03051191 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 66

Last updated 2020-10-22

No results posted yet for this study

Summary

Subjects with cardiovascular diseases (CVD) have higher incidence of cancers compared to general population. The investigators hypothesized that shared molecular mechanism play a pivotal role in the pathogenesis of CVD including heart failure (HF) and cancers. To address this hypothesis, the investigators are going to explore the expression pattern of micro RNA (miRNA) and cell free DNA (cfDNA) derived from host, gut microbiota and gut microbiota composition extensively in patients with or without CVD, non-ischemic HF (NIHF), and cancers. The participants will be recruited from the outpatient clinic in Sakakibara Heart Institute or Japanese Foundation for Cancer Research. By comparing the expression pattern of miRNA, cfDNA, or gut microbiota composition, the investigators are seeking to find the pathogenic mechanisms shared by those diseases.

Conditions

Interventions

DIAGNOSTIC_TEST

micro RNA

micro RNA, cell free DNA and 16S rRNA genes will be explored cross-sectionally at enrollment.

Sponsors & Collaborators

  • Japanese Foundation for Cancer Research

    collaborator OTHER

  • Sakakibara Heart Institute

    lead OTHER

Principal Investigators

  • Tsutomu Yoshikawa · Sakakibara Heart Institute

Eligibility

Min Age
20 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-01-01
Primary Completion
2019-12-01
Completion
2019-12-01

Countries

  • Japan

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03051191 on ClinicalTrials.gov