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Effects of Commonly Used Medications on Mood and Choice

NCT03652740 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 25

Last updated 2026-02-02

Study results available
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Summary

This non-treatment study will examine how commonly used prescription or over-the-counter medications may influence mood and medication preference.

Conditions

  • Healthy

Interventions

DRUG

Methylphenidate

Methylphenidate hydrochloride is administered orally at 10, 20, and 40 milligeam doses.

DRUG

Nicotine

Nicotine is administered orally via capsule at 1, 2, 3 and 4 milligram doses.

DRUG

Placebo

Capsules will contain a commonly prescribed or over-the-counter medication, or placebo. A placebo is an inactive substance that looks like the study drug, but contains no active drug.

Sponsors & Collaborators

Principal Investigators

  • Dustin C Lee, Ph.D. · Johns Hopkins University

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-10-02
Primary Completion
2024-02-01
Completion
2024-02-01
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Drugs
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03652740 on ClinicalTrials.gov