Persisting Effects of Psilocybin
NCT02971605 · Status: COMPLETED · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 13
Last updated 2019-09-10
Summary
The proposed pilot study will assess whether ingestion of a classic hallucinogen (psilocybin) leads to changes in emotion processing and neural circuitry that may predict repeated self-administration of this drug and underlie an atypical mechanism of abuse liability, which may vitally contribute to the understanding of the potential for abuse and the underlying mechanisms supporting abuse of classic hallucinogens.
Conditions
- Healthy
Interventions
- DRUG
-
25 mg/70 kg Psilocybin
Sponsors & Collaborators
-
National Institute on Drug Abuse (NIDA)
collaborator NIH - lead OTHER
Principal Investigators
-
Frederick S Barrett, PhD · Johns Hopkins University
Study Design
- Allocation
- NA
- Purpose
- BASIC_SCIENCE
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Max Age
- 45 Years
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2017-07-01
- Primary Completion
- 2018-08-21
- Completion
- 2018-08-21
- FDA Drug
- Yes
Countries
- United States
Study Locations
More Related Trials
-
Qualitative Study About Psychedelics Using in Psychiatric Disorders
NCT06014164 ·Status: NOT_YET_RECRUITING
-
UW Psilocybin Pharmacokinetics Study
NCT02163707 ·Status: COMPLETED ·Phase: PHASE1
-
Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic Psychedelics
NCT06624137 ·Status: RECRUITING
-
Direct Comparison of Altered States of Consciousness Induced by LSD and Psilocybin
NCT03604744 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
Comparative Acute Effects of LSD, Psilocybin and Mescaline
NCT04227756 ·Status: COMPLETED ·Phase: PHASE1
-
Effects of Drugs on Responses to Brain and Emotional Processes
NCT04053036 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
Investigation of Psychedelic Effects in Psychoactive Substances
NCT06772753 ·Status: RECRUITING ·Phase: PHASE1
-
Study of the Safety and Feasibility of Psilocybin in Adults With Methamphetamine Use Disorder
NCT05322954 ·Status: TERMINATED ·Phase: PHASE1
-
Wellcome Leap Psilocybin for OUD
NCT06786325 ·Status: RECRUITING ·Phase: PHASE2
-
Neurodynamics of Prosocial Emotional Processing Following Serotonergic Stimulation With N,N-Dimethyltryptamine (DMT) and Harmine in Healthy Subjects
NCT04716335 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
Does Serotonin System Stimulation Increase Pro-social Behavior? - A Comparative Pharmacological Neuroscientific Study in Healthy Humans
NCT06081179 ·Status: COMPLETED ·Phase: PHASE1
-
Acute Effects of MDMA Co-administration on the Response to Psilocybin in Healthy Subjects
NCT06884514 ·Status: RECRUITING ·Phase: PHASE1
-
Human Psychopharmacology of Salvinorin A
NCT00996411 ·Status: COMPLETED ·Phase: PHASE1
-
Mood and Cognitive Effects of Psilocybin in Healthy Participants
NCT05252598 ·Status: WITHDRAWN ·Phase: EARLY_PHASE1
-
Mindfulness and Psychedelics
NCT05780216 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
Direct Comparison of Altered States of Consciousness Induced by LSD, Psilocybin, and DMT in Healthy Participants
NCT06899334 ·Status: RECRUITING ·Phase: PHASE1
-
Antidepressant Response of DMT Masked With Propofol
NCT06927076 ·Status: RECRUITING ·Phase: NA
-
Shifting Brain Excitation-Inhibition Balance in Autism Spectrum Disorder
NCT03537950 ·Status: COMPLETED ·Phase: NA
-
Acute Analgesic Effects of DMT on Experimentally Induced Pain in Healthy Participants
NCT06180759 ·Status: COMPLETED ·Phase: PHASE1
-
Acute Effects of 2C-B Compared With MDMA and Psilocybin in Healthy Subjects
NCT05523401 ·Status: COMPLETED ·Phase: PHASE1
-
Examining the Role of Tolerance on Dose-dependent Effects of Acute THC on Oculomotor and Cognitive Performance
NCT06351540 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1
-
Cannabinoids, Neural Synchrony, and Information Processing
NCT00708994 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
Role of Serotonin in Acute and Subacute MDMA Effects
NCT00838305 ·Status: COMPLETED ·Phase: NA
-
Digital Intervention for Psychedelic Preparation (DIPP): Comparing Meditation and Music-Based Programs
NCT06815653 ·Status: RECRUITING ·Phase: PHASE1
-
Effects of Stimulants on Behavioral and Neural Markers of Social Motivation, Ability, and Neural Markers of Social Function
NCT05379959 ·Status: COMPLETED ·Phase: EARLY_PHASE1