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Whether Using Sequential pH Would Improve Human Blastocyst Formation

NCT03641014 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 1312

Last updated 2019-07-16

No results posted yet for this study

Summary

Any drift in extracellular pH (pHe) from the intercellular pH (pHi) could alter the mechanism regulating transporters and exchangers through the plasma membrane. This could lead to difficulty in restoring the physiological level of pHi. The critical stages that lack robust mechanism of regulating the pHi are the denuded oocyte, early stage of fertilization or a thawed embryo. This, in turn, could lead to a significant effect of the perturbations on embryo development. Convincing evidence regarding the optimal pHe for culturing human embryo is, so far, scanty and mostly anecdotal. The embryo has been reported to have a compensatory mechanism to grow at pHe between 7.0-7.4. Others have recommended that embryo need a sequential pH to viably grow suggesting that the post-genomic activation stage needs a slightly alkaline range of pH. However, whether this holds true remains to be examined.

Conditions

Interventions

OTHER

pH Effect on blastocyst formation

to investigate which pH is suitable for each stage of embryo development

Sponsors & Collaborators

  • Banoon IVF Center

    collaborator OTHER

  • Quena IVF Centre

    collaborator UNKNOWN

  • Ibn Sina Hospital

    lead OTHER_GOV

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-08-28
Primary Completion
2019-05-30
Completion
2019-06-10

Countries

  • Egypt

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03641014 on ClinicalTrials.gov