Azithromycin is a macrolide-class antibiotic used to treat a broad range of bacterial infections, including respiratory, ENT, skin, and sexually transmitted infections. It is available in oral, intravenous, and ophthalmic forms and marketed under brands such as Zithromax. It is a widely prescribed generic medicine.
The U.S. FDA approved Nuzolvence (zoliflodacin), a single-dose oral treatment for uncomplicated urogenital gonorrhea, based on a non-inferiority Phase 3 trial. Thailand also authorized the drug under the brand Nuzolvance, expanding access in low- and middle-income countries.
Research shows chloramine disinfection successfully stopped a Legionnaires' disease outbreak in Minnesota, while clinical data reveals Legionella pneumonia has 11.9% 30-day mortality and disproportionately affects immunocompromised patients. The studies highlight both prevention strategies and diagnostic challenges.
Researchers have developed an inhalable nanoparticle system for delivering rifampin directly to the lungs, potentially reducing tuberculosis treatment from daily to once-weekly dosing while lowering side effects and improving drug effectiveness.
The CDC is investigating a multistate outbreak of extensively drug-resistant Salmonella Newport with an NDM-1 gene linked to Rosabella moringa powder capsules, marking the first documented outbreak of Salmonella with an NDM-1 gene in the United States.
CDC and FDA are investigating a multistate outbreak of extensively drug-resistant Salmonella Newport infections linked to Rosabella brand moringa powder capsules, with seven people sickened across seven states and three requiring hospitalization.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07780292 |
Effect of Post Operative Low Dose Oral Azithromycin in Chronic Rhinosinusitis Patients With Nasal Polyps |
NOT_YET_RECRUITING | PHASE4 |
| NCT07777952 |
Adjunctive 308-nm Excimer Light With Oral Azithromycin for Inflammatory Acne |
COMPLETED | NA |
| NCT07713186 |
Azithromycin in Atopic Dermatitis |
NOT_YET_RECRUITING | PHASE4 |
| NCT07615842 |
Assessing the Impact of Unnecessary Antibiotic Treatment on the Development of Appropriate Adaptive Immune Responses in Malnourished Bangladeshi Infants |
NOT_YET_RECRUITING | PHASE1 |
| NCT07608328 |
Azithromycin to Modify Bronchiectasis Exacerbation Risk |
NOT_YET_RECRUITING | PHASE4 |
| NCT07433426 |
The Impact of Shigellosis and Recommended Treatment in Children |
RECRUITING | PHASE2 |
| NCT07394725 |
Unlocking New Avenues: Azithromycin Vs Erythromycin in Pre-term, Pre-mature Rupture of Membrane Management |
COMPLETED | PHASE1 |
| NCT07314281 |
Meropenem vs Azithromycin Efficacy in Case XDR Enteric Fever |
RECRUITING | PHASE4 |
| NCT07306234 |
Doxycycline vs. Macrolide for MRMP (DOMINO) |
NOT_YET_RECRUITING | PHASE4 |
| NCT07213765 |
Short-term Antibiotic Therapy in Mycobacterium Avium Complex Pulmonary Disease |
RECRUITING | PHASE4 |
