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Genetic Polymorphism and Post Operative Nausea and Vomiting (PONV)

NCT03627780 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 300

Last updated 2021-05-19

No results posted yet for this study

Summary

Nausea and vomiting affects 25-30% of individuals in the post-operative period and can reach more than 70-80% in high-risk patients. inherited factors may play a significant role in individual susceptibility and clinical research on hereditary factors involved in the pathogenesis of Postoperative nausea and vomiting (PONV) and chemotherapy nausea and vomiting (CINV) is relatively new. The aim of this study is to investigate whether inter-individual differences related to PONV are associated with genetic factors. 300 patients will be evaluated in postoperative oncological surgeries. The peripheral leukocyte DNA will be extracted by the Salting Out Procedure method and processed to genotyping for 48 SNPs from 15 candidate genes by real-time PCR by the Taqman method. The possible associations with demographic data and factors related to surgery will be analyzed by univariate and multivariate analysis.

Conditions

  • Genetic Predisposition to Disease
  • Postoperative Nausea
  • Polymorphism, Genetic

Interventions

DIAGNOSTIC_TEST

DNA extraction

DNA will be extracted from white cells

Sponsors & Collaborators

  • Fundação de Amparo à Pesquisa do Estado de São Paulo

    collaborator OTHER_GOV

  • Instituto do Cancer do Estado de São Paulo

    lead OTHER

Principal Investigators

  • Angela M Sousa, phd · Instituto do Cancer do Estado de São Paulo

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-01-02
Primary Completion
2020-03-01
Completion
2020-03-01

Countries

  • Brazil

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03627780 on ClinicalTrials.gov