Can Cognitive Training Decrease Reactive Aggression?

Summary

The purpose of the study is to examine the effects of cognitive training on emotion regulation, impulse control, and aggression in people with schizophrenia. The study compares a combination of computerized cognitive remediation and social cognition training (CRT+SCT) to cognitive remediation alone (CRT). Study outcomes include multiple measures of aggression, emotion regulation, impulse control, cognition, and symptoms.

Conditions

• Schizophrenia
• Cognitive Deficits
• Impulsive Aggression
• Emotion
• Impulsivity

Interventions

BEHAVIORAL

Cognitive Remediation (CRT)

Study compares two configurations of cognitive training--computerized cognitive remediation versus a combination of computerized cognitive remediation and social cognition training. The cognitive remediation therapy group will complete computerized training activities in attention, memory, processing speed, problem solving, and executive functions.

BEHAVIORAL

CRT+ Social Cognition Training

Study compares two configurations of cognitive training--computerized cognitive remediation versus a combination of computerized cognitive remediation and social cognition training. The combined cognitive remediation and social cognition training group will complete computerized training that target neurocognitive functions, facial affect emotion recognition and mentalizing tasks.

Sponsors & Collaborators

• Brain & Behavior Research Foundation

  collaborator OTHER

• National Center for Advancing Translational Sciences (NCATS)

  collaborator NIH

• Nathan Kline Institute for Psychiatric Research

  collaborator OTHER

• Weill Medical College of Cornell University

  lead OTHER

Principal Investigators

• Anthony O Ahmed, PhD · Weill Medical College of Cornell University

• Jean-Pierre Lindenmayer, MD · Manhattan Psychiatric Center

• Matthew J Hoptman, PhD · Nathan Kline Institute for Psychiatric Research

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

60 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2016-08-16

Primary Completion

2019-10-25

Completion

2019-10-25

Countries

• United States

Study Locations