Remediation of Visual Perceptual Impairments in People With Schizophrenia

Summary

The purpose of this study is to evaluate the effectiveness of a visual remediation intervention for people with schizophrenia. The intervention targets two visual functions that much research has shown are impaired in many people with the disorder, namely contrast sensitivity and perceptual organization. The first phase of the study will test the effects of interventions targeting each of these processes, as well as the effects of a combined package. A control condition of higher-level cognitive remediation is included as a fourth condition. The second phase of the study will evaluate the effectiveness of the most effective intervention from the first phase, but in a new and larger sample of individuals. Outcome measures include multiple aspects of visual functioning, as well as visual cognition and overall community functioning.

Conditions

• Schizophrenia
• Schizoaffective Disorder

Interventions

BEHAVIORAL

UltimEyes

A computer program developed to improve contrast sensitivity and visual acuity.

BEHAVIORAL

Contour Integration Training

A computerized program to improve contour integration (a form of perceptual organization).

BEHAVIORAL

UltimEyes + Contour Integration Training

The combination of UltimEyes and Contour Integration Training

BEHAVIORAL

MyBrainSolutions

A computer program consisting of exercises to improve cognition (attention, memory, planning) and to facilitate goal setting.

Sponsors & Collaborators

• New York University

  collaborator OTHER

• Weill Medical College of Cornell University

  collaborator OTHER

• National Institute of Mental Health (NIMH)

  collaborator NIH

• University of Rochester

  lead OTHER

Principal Investigators

• Steven M Silverstein, Ph.D. · University of Rochester

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

60 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2018-06-01

Primary Completion

2025-03-31

Completion

2025-05-31

Countries

• United States

Study Locations