MedTrace Logo

Rolandic Epilepsy Genomewide Association International Study

NCT03547050 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 210

Last updated 2023-10-06

No results posted yet for this study

Summary

We have discovered a small change in the genetic code which increases the risk of the brainwave abnormality that is found in rolandic epilepsy. We now wish to confirm this using a second much larger sample of patients. We will investigate the other genetic changes that cause people with the brainwave abnormality to develop seizures, as well as problems with speech, coordination, attention and learning.

Conditions

  • Rolandic Epilepsy

Interventions

OTHER

Blood draw

Participation includes one visit for one blood draw per recruited patient. 10-20ml peripheral venous blood will be taken from the antecubital fossa. The DNA from the blood sample will then be extracted and resequenced for analysis.

OTHER

Existing samples

Control DNA samples will be used that have been previously acquired in other studies.

Sponsors & Collaborators

  • King's College Hospital NHS Trust

    collaborator OTHER

  • Guy's and St Thomas' NHS Foundation Trust

    collaborator OTHER

  • Cardiff University

    collaborator OTHER

  • The Hospital for Sick Children

    collaborator OTHER

  • Hospital JP Garrahan

    collaborator OTHER_GOV

  • Aghia Sophia Children's Hospital of Athens

    collaborator OTHER

  • Hospital Mutua de Terrassa

    collaborator OTHER

  • Seattle Children's Hospital

    collaborator OTHER

  • Hasbro Children's Hospital

    collaborator OTHER

  • Columbia University

    collaborator OTHER

  • King's College London

    lead OTHER

Eligibility

Min Age
6 Years
Max Age
25 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-06-01
Primary Completion
2023-03-17
Completion
2023-06-30

Countries

  • United States
  • Argentina
  • Canada
  • Greece
  • Italy
  • Spain
  • United Kingdom

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03547050 on ClinicalTrials.gov