Biology of Juvenile Myoclonic Epilepsy

Summary

The investigators are collecting genetic information through blood samples as well as clinical and EEG data from over 1000 people with Juvenile Myoclonic Epilepsy (JME) across the UK, Europe and North America. This study will draw on both existing and new samples from JME patients. These will be compared to anonymised data from samples for 2000 controls. The goal of this study is to find the genetic cause of JME. Finding the cause will help create better treatments for JME, as well as improve patient outcomes by allowing us to detect it earlier.

Conditions

• Juvenile Myoclonic Epilepsy

Interventions

OTHER

Blood draw

Participation includes one visit for one blood draw per recruited patient. 10-20ml peripheral venous blood will be taken from the antecubital fossa. The DNA from the blood sample will then be extracted and resequenced for analysis.

OTHER

Existing samples

Control DNA samples will be used that have been previously acquired in other studies.

Sponsors & Collaborators

• King's College Hospital NHS Trust

  collaborator OTHER

• Charles University, Czech Republic

  collaborator OTHER

• Hopital Universitaire Robert-Debre

  collaborator OTHER

• Vestre Viken Hospital Trust

  collaborator OTHER

• The Hospital for Sick Children

  collaborator OTHER

• Cardiff University

  collaborator OTHER

• Odense University Hospital

  collaborator OTHER

• King's College London

  lead OTHER

Principal Investigators

• K Pal, MD PhD · King's College London

Eligibility

Min Age

10 Years

Max Age

40 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2017-07-13

Primary Completion

2026-06-30

Completion

2026-12-31

Countries

• United States
• Canada
• Czechia
• Denmark
• Estonia
• France
• Italy
• Norway
• United Kingdom

Study Locations