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REVEAL Biomarkers of Engraftment After Alternative Donor HSCT

NCT03541889 · Status: RECRUITING · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 56

Last updated 2026-03-05

No results posted yet for this study

Summary

The purpose of this study is to find new tests that could help determine if the newly infused bone marrow cells are growing well after bone marrow transplantation or if new bone marrow cells are needed. The Investigator will use FLT imaging, an investigational imaging test, and collect blood samples to investigate whether the cells are growing well.

Conditions

  • Primary Graft Failure

Interventions

DRUG

FLT imaging and TK1 blood measurements

F18 labeled thymidine PET/CT scans will be performed. Serum measurements of TK1 will be obtained.

Sponsors & Collaborators

  • Emory University

    collaborator OTHER

  • University of Michigan

    collaborator OTHER

  • University Hospitals Cleveland Medical Center

    collaborator OTHER

  • National Heart, Lung, and Blood Institute (NHLBI)

    collaborator NIH

  • University of Oklahoma

    lead OTHER

Principal Investigators

  • Kirsten Williams, MD · Emory University

Study Design

Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
4 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-02-05
Primary Completion
2026-11-30
Completion
2027-11-30
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03541889 on ClinicalTrials.gov