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Cerebrospinal Acid-base in Pregnant and Non-pregnant Fertile Women

NCT03496311 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 40

Last updated 2018-04-17

No results posted yet for this study

Summary

The third trimester of pregnancy is typically characterized by the development of a marked respiratory alkalosis. The possible role of pregnancy-induced variations of cerebrospinal fluid (CSF) acid-base characteristics on the development of hypocapnic alkalosis is still unknown.

Aim of this study is to characterize, according to Stewart's approach, the acid-base equilibrium of CSF and arterial plasma of pregnant women and compare the results with data obtained from fertile, non-pregnant women.

Conditions

  • Acid-Base Imbalance
  • Respiratory Alkalosis
  • Cerebrospinal Fluid
  • Pregnancy

Interventions

DIAGNOSTIC_TEST

Acid - Base characterization

Samples of cerebrospinal fluid and arterial blood will be collected anaerobically to measure acid-base variables, electrolytes, albumin, progesterone and copeptin levels

Sponsors & Collaborators

  • University of Milan

    collaborator OTHER

  • Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

    lead OTHER

Principal Investigators

  • Thomas Langer, MD · University of Milan

  • Antonio Pesenti, MD · University of Milan

  • Edoardo Calderini, MD · Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico di Milano

  • Giorgio Giudici, MD · University of Milan

  • Mariateresa Ambrosini, MD · Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico di Milano

Eligibility

Min Age
18 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-04-13
Primary Completion
2019-04-30
Completion
2019-04-30

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03496311 on ClinicalTrials.gov