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Cerebral Perfusion in Hypothermic Circulatory Arrest

NCT03484104 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 40

Last updated 2021-09-29

No results posted yet for this study

Summary

Selective antegrade cerebral perfusion (sACP) during aortic arch surgery in hypothermic circulatory arrest (HCA) is an established method for intraoperative neuroprotection. Although sACP is established as a beneficial method to reduce secondary neurological side effects due to brain-malperfusion, there are several parameters like sACP flow rate, perfusion pressure or temperature of the perfusate, where the optimal values remain unclear. The flow rate of the sACP-perfusate is increased according to center-specific standard-procedures. The optimal sACP flow rate, monitored by near infrared spectroscopy (NIRS), is to be investigated in this single center clinical prospective observational study. 40 Patients are enrolled over an estimated period of 14 months.

Conditions

  • Cerebrovascular Circulation

Interventions

DIAGNOSTIC_TEST

Measurement of tissue oxygenation index (TOI)

TOI and Vmca measurement during cardiac surgery with hypothermic circulatory arrest

Sponsors & Collaborators

  • Insel Gruppe AG, University Hospital Bern

    lead OTHER

Principal Investigators

  • Gabor Erdoes, MD PhD · University of Bern

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-07-01
Primary Completion
2021-09-28
Completion
2021-09-28

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03484104 on ClinicalTrials.gov