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Evaluation of Aortic Stiffness as a Prognostic Indicator of Aortic Dilatation in Patients With Bicuspid Aortic Valve by Multimodal Imaging

NCT03474159 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 100

Last updated 2025-02-14

No results posted yet for this study

Summary

The objective is the development and validation of morphological markers informative of aortic dilatation in order to improve the precision of the risk of aneurysm of the thoracic aorta and of acute aortic syndrome for patients with bicuspid aortic valve (BAV).

The primary objective of this study is to demonstrate a correlation between the aortic local pulse wave velocity (PWV) measured with MRI and the progression of the thoracic aorta diameters measured by MRI after a follow-up of 2 years.

Conditions

  • Bicuspid Aortic Valve

Interventions

DEVICE

Magnetic Resonance Imaging

Aortic distensibility measured in MRI at the Valsalva sinus and at the ascending tubular aortic level

DEVICE

Transthoracic echocardiography

Aortic distensibility measured in TTE of the same segments in TM and in B mode

DEVICE

Echography UltraFast

Carotid pulse rate measured on carotid arteries by UF

Sponsors & Collaborators

  • Institut National de la Santé Et de la Recherche Médicale, France

    collaborator OTHER_GOV

  • Centre National de la Recherche Scientifique, France

    collaborator OTHER

  • French Cardiology Society

    lead OTHER

Principal Investigators

  • Emmanuel MESSAS · APHP

Study Design

Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-11-07
Primary Completion
2024-09-24
Completion
2024-09-24

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03474159 on ClinicalTrials.gov