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Cardiac MRI for Severe Aortic Stenosis

NCT01638156 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 39

Last updated 2023-08-01

No results posted yet for this study

Summary

This study will evaluate the importance of arterial stiffness and wave reflections as determinants of persistent left ventricular (LV) hypertrophy and fibrosis (assessed using cardiac magnetic resonance imaging \[MRI\]) after correction of severe stenosis of the aortic valve. The hypothesis will test whether stiff arteries and increased wave reflections impede pumping of blood by the LV after aortic valve replacement (AVR)and precent adequate regression (improvement) of hypertrophy and fibrosis of the myocardium despite correction of aortic valve stenosis.

Conditions

  • Aortic Stenosis

Sponsors & Collaborators

  • Pennsylvania Department of Health

    collaborator OTHER_GOV

  • American College of Radiology

    lead OTHER

Principal Investigators

  • Scott Akers, MD, PhD · Philadelphia Veterans Administration Medical Center

  • Julio A. Chirinos, MD · Philadelphia Veterans Administration Medical Center

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-06-30
Primary Completion
2015-12-31
Completion
2015-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01638156 on ClinicalTrials.gov